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Abstract The trans-Neptunian object (58534) 1997 CQ₂₉(a.k.a. Logos) is a resolved wide binary in the dynamically Cold Classical population. With Hubble Space Telescope resolved observations where the primary Logos is well separated from its secondary Zoe it can be established that Logos has a time-variable brightness. Logos’ brightness varied by several tenths of a magnitude over a short timescale of hours while the brightness variability of Zoe was on a longer timescale. New unresolved ground-based observations obtained with the Lowell Discovery Telescope and the Magellan-Baade telescope confirm at least one highly variable component in this system. With our ground-based observations and photometric constraints from space-based observations, we suggest that the primary Logos is likely a close/contact binary whose rotational period is 17.43 ± 0.06 hr for a lightcurve amplitude of 0.70 ± 0.07 mag, while Zoe is potentially a (very) slow rotator with an unknown shape. Using theCandelasoftware, we model the Logos-Zoe system and predict its upcoming mutual events season using rotational, physical, and mutual orbit parameters derived in this work or already published. Zoe’s shape and rotational period are still uncertain, so we consider various options to better understand Zoe. The upcoming mutual event season for Logos-Zoe starts in 2026 and will last for four years with up to two events per year. Observations of these mutual events will allow us to significantly improve the physical and rotational properties of both Logos and Zoe. 

We developed a computational model of sodium fluorescein (SF) biliary excretion in ex vivo machine perfusion and used this model to assess changes in model parameters associated with the activity of MRP2, a hepatocyte membrane transporter, in response to increasing warm ischemia time. We found a significant decrease in the parameter value describing MRP2 activity, consistent with a role of decreased MRP2 function in ischemia-reperfusion injury leading to decreased secretion of SF into bile. 

Abstract The 5:3 and 7:4 mean motion resonances of Neptune are at 42.3 and 43.7 au, respectively, and overlap with objects in the classical trans-Neptunian belt (Kuiper Belt). We report the complete/partial lightcurves of 13 and 14 trans-Neptunian objects (TNOs) in the 5:3 and 7:4 resonances, respectively. We report a most likely contact binary in the 7:4 resonance, 2013 FR₂₈, with a periodicity of 13.97 ± 0.04 hr and a lightcurve amplitude of 0.94 ± 0.02 mag. With a V-/U-shaped lightcurve, 2013 FR₂₈has one of the largest well-sampled TNO amplitudes observed with ground-based observations, comparable to the well-determined contact binary 2001 QG₂₉₈. 2013 FR₂₈has a mass ratioq∼ 1 with a densityρ∼ 1 g cm⁻³. We find several objects with large amplitudes and classify 2004 SC₆₀, 2006 CJ₆₉, and 2013 BN₈₂as likely contact binaries and 2001 QF₃₃₁, 2003 YW₁₇₉, and 2015 FP₃₄₅as likely elongated objects. We observe the 17:9 resonant or classical object 2003 SP₃₁₇that we classify as a likely contact binary. A lower estimate of 10%–50% and 20%–55% for the fraction of (nearly) equal-sized contact binaries is calculated in the 5:3 and 7:4 resonances, respectively. Surface colors of 2004 SC₆₀, 2013 BN₈₂, 2014 OL₃₉₄, and 2015 FP₃₄₅have been obtained. Including these colors with ones from the literature reveals that elongated objects and contact binaries share the same ultrared surface color, except Manwë–Thorondor and 2004 SC₆₀. Not only are the colors of the 7:4 and 5:3 TNOs similar to the cold classicals, but we demonstrate that the rotational properties of the 5:3 and 7:4 resonants are similar to those of the cold classicals, inferring a clear link between these subpopulations. 

Abstract We report the discovery of cometary activity in the form of a pronounced tail emanating from Near-Earth Object (523822) 2012 DG₆₁, identified in UT 2024 April 18 Dark Energy Camera images by our AI assistant TailNet. TailNet is an AI designed to filter out images unlikely to show activity for volunteers of our NASA Partner “Active Asteroids” Citizen Science campaign, from which our AI is trained. Subsequently, our archival investigation revealed 2012 DG61 is recurrently active after we found it displaying a pronounced tail in a UT 2018 April 16 Steward Observatory Bart Bok 2.3 m telescope image and UT 2018 May 14 observations by G. Borisov with the 0.3 m telescope at MARGO Observatory. Our dynamical integrations reveal that 2012 DG61, an Apollo dynamical class member, is likely in 2:1 mean-motion resonance with Jupiter. We encourage additional observations to help characterize the activity morphology of this near-Earth comet. 

Abstract SummaryMolecular mechanisms of biological functions and disease processes are exceptionally complex, and our ability to interrogate and understand relationships is becoming increasingly dependent on the use of computational modeling. We have developed “BioModME,” a standalone R-based web application package, providing an intuitive and comprehensive graphical user interface to help investigators build, solve, visualize, and analyze computational models of complex biological systems. Some important features of the application package include multi-region system modeling, custom reaction rate laws and equations, unit conversion, model parameter estimation utilizing experimental data, and import and export of model information in the Systems Biology Matkup Language format. The users can also export models to MATLAB, R, and Python languages and the equations to LaTeX and Mathematical Markup Language formats. Other important features include an online model development platform, multi-modality visualization tool, and efficient numerical solvers for differential-algebraic equations and optimization. Availability and implementationAll relevant software information including documentation and tutorials can be found at https://mcw.marquette.edu/biomedical-engineering/computational-systems-biology-lab/biomodme.php. Deployed software can be accessed at https://biomodme.ctsi.mcw.edu/. Source code is freely available for download at https://github.com/MCWComputationalBiologyLab/BioModME. 

Abstract We report the discovery of cometary activity from minor planet 2011 UG₁₀₄, which we classify as a Jupiter Family Comet (JFC). This discovery was aided by our Artificial Intelligence (AI) classification system:TailNet. JFC's, short-period comets with eccentric Jupiter-crossing orbits, originate from the Kuiper Belt and thus give us unique insight into the composition and distribution of volatiles in the outer solar system, past and present. Our AI assistantTailNetfirst classified 2011 UG₁₀₄as active, which was affirmed by Citizen Scientists on our NASA Partner ProgramActive Asteroids. Through further archival image searches our science team found evidence of activity on 2011 UG₁₀₄on three separate observations from 2021 February to 2021 April (81.°8 < f < 95.°0).